Mode of Action
Description
Dosage and Administration
Presentation |
 HEPASOLV™, Heparin Sodium in is a heterogeneous group of straight-chain anionic mucopolysaccharides, called glycosaminoglycans having anticoagulant properties. Heparin Sodium Injection is a sterile solution of heparin sodium derived from bovine lung tissue, standardized for anticoagulant activity.
Mode of Action
Heparin Sodium inhibits reactions that lead to the clotting of blood and the formation of fibrin clots. Heparin acts at multiple sites in the normal coagulation system. Small amounts of heparin sodium in combination with antithrombin III (heparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of heparin sodium can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Heparin sodium also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor. Bleeding time is usually unaffected by heparin sodium. Clotting time is prolonged by full therapeutic doses of heparin sodium.
Description
- Prophylaxis and treatment of venous thrombosis and its extension
- Unstable angina / Post myocardial infarction
- Pulmonary embolism in patients undergoing major abdomino-thoracic surgery
- Atrial fibrillation at risk of embolisms
- Prevention of intravascular coagulation during cardiac & vascular surgeries
- Prophylaxis and treatment of peripheral arterial embolism
- Blood transfusions, extracorporeal circulation e.g. dialysis procedures
- Patients with or at risk of Disseminated intravascular coagulation
- In medical systemic illness e.g., stroke, long standing catheters in situ
Dosage and Administration |
| ROUTE OF ADMINISTRATION |
FREQUENCY |
RECOMMENDED DOSE* |
Deep Subcutaneous
Injection |
Initial Dose |
5,000 Units by IV Stat injection followed by 10,000 to 20,000 Units |
| Intermittent Intravenous Injection |
Every 4 to 6 hours |
5,000 to 10,000 Units |
Continuous Intravenous
Infusion |
Initial Dose |
5,000 Units by IV injection |
| Continuous |
20,000 to 40,000 Units/ 24 hours |
|
Presentation
HEPASOLV™ is available in easy dispensable dosage presentations of 1000, 5000 and 25000 IU per ml with total volume of 5ml in vials. |
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