COVAXIN™ (BBV152) Shows Demonstration of Protective Efficacy and Immunogenicity in Non-Human Primates
SALIENT FEATURES –
- A 2-dose vaccination regimen of inactivated SARS-CoV-2 vaccine candidates was administered in 20 rhesus macaques (divided into four groups equally).
- One group was administered with placebo, while three groups were immunized with 3 different vaccine candidates at 0 and 14 days. All the macaques were exposed to viral challenge 14 days after the 2nd dose.
- The results showed protective efficacy, increasing SARS-CoV-2 specific IgG and neutralizing antibodies, reducing replication of the virus in the nasal cavity, throat, and lung tissues of monkey.
- No evidence of pneumonia was observed by histopathological examination in vaccinated groups, unlike the placebo group
- Adverse events were not seen in animals immunized with a two-dose vaccination regimen.
To summarize, the vaccine candidate was found to generate robust immune responses. Thus, preventing infection and disease in the primates upon high amounts of exposure to live SARS-CoV-2 virus.
Kindly click the link for publication: (https://www.nature.com/articles/s41467-021-21639-w)
38 comments
Having successfully developed and manufactured several other inactivated viral vaccines, Bharat Biotech once again demonstrated it’s proven expertise to produce safe and immunogenic COVAXIN in sub human primates prior to the ongoing human clinical trials. Welcome COVAXIN!
Great. Hope you come out with an effective vaccine
Congratulations
Congratulations # BHARAT_BIO_TECH….
YOU ONLY CAN DO IT…👌👍
Congratulations # BHARAT_BIO_TECH….
YOU ONLY CAN DO IT
Congratulations to all your team members
Congratulations! This the first step towards the success.
As the name itself suggest Bharat Biotech Your are the hope for Entire Bharat Congratulations!
Congratulations , hope you role out the much needed vaccines as soon as possible
FOR BBIL IT WAS OBVIOUS TO ACHIEVE THIS SUCCESS .👍
Congratulations 🇮🇳 💐💐💐💐✅
Heartly congratulations to Bharat Biotech
Congratulations !
CongratulationZ Bharat Biotech & hope the vaccine comes out effectively & fast.We are all waiting for it.
Congratulations
Congratulations
Well done
We all kniw that india is the vaccine hub in entire world so we expect that bharat biotech wiil be success and provide soon jay jagannath
Congratulations on this achievement. Hope this is replicated In humans nd we have effective vaccine against this covid2019 virus. You are going to make India proud
When will the vaccine be available and in what quantities? Phase 2 trials could have been started by mid Aug, I think. People are eagerly waiting for an effective vaccine to return to normal life. It should be available in market too.
Be proud to be Indian.
Congratulations Bharat biotech and Team
A leap to Mankind !
Congratulations Team Bharath biotech💐
Great work and much needed at this hour
Congratulations
Congratulations.
Hope give Everything , Hope Brings everything & Hope shows way to live ….Your the Hope for Survival of Covid
Congratulations # BHARAT_BIO_TECH.
Congratulations BHARAT_BIO_TECH.
congratulations, may the 1 vaccine developed be INDIAN.
Great achievement…. congratulations
Congratulations 🎉
आपकी टीम को दिल से बधाई देते है
Congratulations, and further hope for the best and also hope soon your vaccine should be available after all trials in the market. Thanks
Great News… Congratulations Team….
Hoping for good results…. For all trials which are remaining and hoping covaxin should be available in the market soon.
Thank you so much ✌🏻
BBL is a confident candidate to produce the vaccine safely and for sure reliable n trustworthy . GOI must promote indigenous manufacturers to get approvals and recognition . Best wishes.
Dr S. L. Hoti
Very encouraging results and a great hope. Wish all the best to Bharat Biotech for turning hope into a reality .
Congratulations….
All the best for Bharath Biotech & indeed a great news for the entire human beings….