COVAXIN™ – Animal Study Results

by Bharatbiotech
37 comments 9723 views

COVAXIN™ (BBV152) Shows Demonstration of Protective Efficacy and Immunogenicity in Non-Human Primates

Disclaimer* – [Please read below]

SALIENT FEATURES –

  • A 2-dose vaccination regimen of inactivated SARS-CoV-2 vaccine candidates was administered in 20 rhesus macaques (divided into four groups equally).
  • One group was administered with placebo, while three groups were immunized with 3 different vaccine candidates at 0 and 14 days. All the macaques were exposed to viral challenge 14 days after the 2nd dose.
  • The results showed protective efficacy, increasing SARS-CoV-2 specific IgG and neutralizing antibodies, reducing replication of the virus in the nasal cavity, throat, and lung tissues of monkey.
  • No evidence of pneumonia was observed by histopathological examination in vaccinated groups, unlike the placebo group
  • Adverse events were not seen in animals immunized with a two-dose vaccination regimen.

To summarize, the vaccine candidate was found to generate robust immune responses. Thus, preventing infection and disease in the primates upon high amounts of exposure to live SARS-CoV-2 virus.

Kindly press this link for more info (https://doi.org/10.21203/rs.3.rs-65715/v1)

*Disclaimer: The provided study information is a preprint publish and has not yet undergone peer review. The findings are provisional and the conclusions/final results may differ.

Forward Looking Statement : [Download PDF]

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37 comments

Harshavardhan September 11, 2020 - 8:05 pm

Having successfully developed and manufactured several other inactivated viral vaccines, Bharat Biotech once again demonstrated it’s proven expertise to produce safe and immunogenic COVAXIN in sub human primates prior to the ongoing human clinical trials. Welcome COVAXIN!

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DrD Das September 11, 2020 - 8:40 pm

Great. Hope you come out with an effective vaccine

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Dr.Nageswara Rao Patnala September 11, 2020 - 8:51 pm

Congratulations

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RAVIKIRAN September 11, 2020 - 9:18 pm

Congratulations # BHARAT_BIO_TECH….
YOU ONLY CAN DO IT…👌👍

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RAVIKIRAN September 11, 2020 - 9:21 pm

Congratulations # BHARAT_BIO_TECH….
YOU ONLY CAN DO IT

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Rajendraprabhu September 12, 2020 - 3:11 pm

Congratulations to all your team members

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Madhu Alampalli September 11, 2020 - 9:25 pm

Congratulations! This the first step towards the success.

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naresh September 11, 2020 - 9:31 pm

As the name itself suggest Bharat Biotech Your are the hope for Entire Bharat Congratulations!

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Bharat Jain September 11, 2020 - 9:36 pm

Congratulations , hope you role out the much needed vaccines as soon as possible

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National vaccines Chandigarh September 11, 2020 - 9:41 pm

FOR BBIL IT WAS OBVIOUS TO ACHIEVE THIS SUCCESS .👍

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Rajender Aleti September 11, 2020 - 9:52 pm

Congratulations 🇮🇳 💐💐💐💐✅

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Rahul Porwal September 11, 2020 - 10:13 pm

Heartly congratulations to Bharat Biotech

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Suryanarayana N September 11, 2020 - 11:24 pm

Congratulations !

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Aneesha Vattikuti September 11, 2020 - 11:35 pm

CongratulationZ Bharat Biotech & hope the vaccine comes out effectively & fast.We are all waiting for it.

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Lokesh purohit September 11, 2020 - 11:52 pm

Congratulations

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Ashutosh Mishra September 12, 2020 - 1:13 am

Congratulations

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Gopi September 12, 2020 - 5:46 am

Well done

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God sniper September 12, 2020 - 6:08 am

We all kniw that india is the vaccine hub in entire world so we expect that bharat biotech wiil be success and provide soon jay jagannath

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Tarandeep Singh September 12, 2020 - 6:12 am

Congratulations on this achievement. Hope this is replicated In humans nd we have effective vaccine against this covid2019 virus. You are going to make India proud

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Yash September 12, 2020 - 6:22 am

When will the vaccine be available and in what quantities? Phase 2 trials could have been started by mid Aug, I think. People are eagerly waiting for an effective vaccine to return to normal life. It should be available in market too.

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Saroj September 12, 2020 - 6:32 am

Be proud to be Indian.

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Dr Milind VAIDYA September 12, 2020 - 8:24 am

Congratulations Bharat biotech and Team

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Shivakumar September 12, 2020 - 8:42 am

A leap to Mankind !
Congratulations Team Bharath biotech💐

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Nitya Nand September 12, 2020 - 9:20 am

Great work and much needed at this hour

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Sooraj September 12, 2020 - 10:05 am

Congratulations

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Sujay Joshi September 12, 2020 - 11:10 am

Congratulations.

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siva raghu ram September 12, 2020 - 11:12 am

Hope give Everything , Hope Brings everything & Hope shows way to live ….Your the Hope for Survival of Covid

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Pramod Jadhav September 12, 2020 - 12:16 pm

Congratulations # BHARAT_BIO_TECH.

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Pramod Jadhav September 12, 2020 - 12:16 pm

Congratulations BHARAT_BIO_TECH.

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Sharad September 12, 2020 - 12:40 pm

congratulations, may the 1 vaccine developed be INDIAN.

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Raja Bhatacharjee September 12, 2020 - 1:03 pm

Great achievement…. congratulations

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Hitesh Panchal September 12, 2020 - 1:33 pm

Congratulations 🎉

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Manoj Kumar Saini September 12, 2020 - 2:31 pm

आपकी टीम को दिल से बधाई देते है

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VINAY PURWAR (PORWAL SURGICALS AND MEDICINE HOUSE,AGRA) September 12, 2020 - 3:59 pm

Congratulations, and further hope for the best and also hope soon your vaccine should be available after all trials in the market. Thanks

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Abhishek Singh September 13, 2020 - 5:19 pm

Great News… Congratulations Team….
Hoping for good results…. For all trials which are remaining and hoping covaxin should be available in the market soon.

Thank you so much ✌🏻

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R Kishore Kumar September 14, 2020 - 7:18 am

BBL is a confident candidate to produce the vaccine safely and for sure reliable n trustworthy . GOI must promote indigenous manufacturers to get approvals and recognition . Best wishes.

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Dr. S L HOTI September 15, 2020 - 7:04 am

Dr S. L. Hoti

Very encouraging results and a great hope. Wish all the best to Bharat Biotech for turning hope into a reality .

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